If you are of the school that is more concerned about content quality and not necessarily fussed about the underlying code that creates it, then any of the WYSIWYG editors will fit the bill perfectly. In this category, if you currently use a lot of Microsoft Office products, then FrontPage 2000 will dovetail quite nicely into your existing application environment (although Drumbeat 2000 is a better product for creating Web sites that connect to Access 2000 databases).
For more free-form Web development and as an overall application, my personal favourite is NetObjects Fusion. Its ease of use, especially when updating entire sites, is far better than its opposition.
If you want the best of both worlds - that is, to use both the WYSIWYG page layout features but also to hand code extensively - then Dreamweaver would be the product of choice.
On the other hand, if you don't want the benefit of page layout capabilities whatsoever, then my picks would be HotDog Professional for top-notch capability, followed by CoffeeCup HTML at a budget level. But don't overlook Arachnophilia, especially if the budget is a consideration.
Picking the best editor for you will be a personal decision based on personal preferences. The good thing about the majority of Web authoring applications is that most of them are available as a free demo download, letting you try out each and see which suits you best.